Tha do thaic gar cuideachadh gus an sgeulachd innse
Bho chòraichean gintinn gu atharrachadh clìomaid gu Large Tech, tha The Impartial air an talamh nuair a tha an sgeulachd a’ leasachadh. Co-dhiù a tha e a’ sgrùdadh ionmhas an pro-Trump PAC aig Elon Musk no a’ toirt a-mach am prògram aithriseach as ùire againn, ‘The A Phrase’, a tha a’ deàrrsadh air na boireannaich Ameireaganach a tha a’ strì airson còraichean gintinn, tha fios againn cho cudromach sa tha e na fìrinnean a sgrùdadh. teachdaireachdan.
Aig àm cho èiginneach ann an eachdraidh nan SA, tha feum againn air luchd-aithris air an talamh. Leigidh an tabhartas agad leinn cumail oirnn a’ cur luchd-naidheachd gus bruidhinn ri gach taobh den sgeulachd.
Tha earbsa aig Ameireaganaich thar an speactram poilitigeach gu lèir anns an Impartial. Agus eu-coltach ri mòran ionadan naidheachdan càileachd eile, tha sinn a’ roghnachadh gun a bhith a’ glasadh Ameireaganaich a-mach às an aithris is mion-sgrùdadh againn le ballachan pàighidh. Tha sinn den bheachd gum bu chòir naidheachdas càileachd a bhith ri fhaighinn leis a h-uile duine, le pàigheadh air a shon leis an fheadhainn as urrainn a phàigheadh.
Bidh an taic agad a’ dèanamh diofar mòr.
Eli Lilly a’ cosg $3 billean eile gus saothrachadh a mheudachadh fhad ‘s a tha an neach-reic dhrogaichean a’ feuchainn ri cinneasachadh cuid de dhrogaichean mòra agus toraidhean san àm ri teachd.
Thuirt Lilly Diardaoin gun leudaich e Siorrachd Kenosha, Wisconsinfactaraidh a cheannaich e tràth am-bliadhna, agus cuidichidh an tasgadh le bhith a’ coinneachadh ri iarrtas a tha a’ sìor fhàs airson toraidhean stealladh leithid an t-siùcair agus drogaichean reamhrachd, Mounjaro agus Zepbound.
Thug na drogaichean sin a-steach $ 4.4 billean còmhla ann an reic airson Lilly anns an treas ràithe am-bliadhna.
Tha an neach-reic dhrogaichean an dùil tòiseachadh air an leudachadh an ath-bhliadhna.
Dh’ ainmich Lilly cuideachd pròiseactan leudachaidh saothrachaidh ioma-billean dolar eile faisg air làimh Indianapolis prìomh oifisean na bu thràithe am-bliadhna.
Thuirt Eli Lilly and Co Diardaoin gu bheil iad air còrr air $ 23 billean a chlàradh gus làraich saothrachaidh a thogail, a leudachadh no fhaighinn air feadh an t-saoghail bho 2020.
From reproductive rights to local weather change to Huge Tech, The Impartial is on the bottom when the story is creating. Whether or not it is investigating the financials of Elon Musk’s pro-Trump PAC or producing our newest documentary, ‘The A Phrase’, which shines a light-weight on the American ladies combating for reproductive rights, we all know how necessary it’s to parse out the information from the messaging.
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The NHS spending watchdog has beneficial Mounjaro – also referred to as tirzepatide and made by Eli Lilly – for these with a physique mass index (BMI) of greater than 35 and no less than one weight-related sickness.
The drug might be rolled out on the NHS progressively over a 12-year interval.
The Nationwide Institute for Well being and Care Excellence (NICE) confirmed on Thursday that individuals with the best wants might be prioritised first, so fewer than 10% of sufferers in England who’re eligible will initially be capable to entry it on the NHS.
Professor Jonathan Benger, chief medical officer at Good, mentioned: “The world will look very totally different in three years which is why we’ve taken the unprecedented determination to evaluate the way in which this medication is delivered to sufferers then.
“Tirzepatide and different medicine prefer it, comparable to semaglutide, will assist individuals dwelling with weight problems to shed weight, and because of this will scale back their threat of creating coronary heart illness or having a stroke.
“However tirzepatide just isn’t for everyone, and solely these with the best medical want might be handled initially.
“This implies many individuals must wait. We have now needed to make this tough determination in an effort to shield different very important NHS providers and likewise to check methods of delivering this new era of weight reduction drugs.”
What’s Mounjaro?
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“Mounjaro is the model title for tirzepatide, a weekly injectable weight-loss remedy which has lately been permitted to be used within the UK and is now out there to order with a prescription on-line,” says Dr Mitra Dutt, GP from Lloyds Pharmacy On-line Physician.“As with most of the weight-loss drugs which have change into out there in recent times, Mounjaro was initially developed and licensed as a drugs for individuals with Sort 2 diabetes.
“Nonetheless, the Medicines and Healthcare merchandise Regulatory Company (MHRA) authorised the drug for weight reduction and weight administration in November 2023 in a bid to deal with weight problems.”
However how does it work?
“The energetic ingredient in Mounjaro is tirzepatide. This works by mimicking the impact of the hormones GIP and GLP-1 that are secreted from the gut after consuming and which sign satiety to the mind, making you’re feeling full,” explains Dr Kathryn Basford at Asda On-line Physician. “It additionally stimulates the discharge of insulin, a blood sugar-lowering hormone, and slows the passage of meals by way of the intestine.
“Over time, this impact will assist weight reduction as individuals eat much less resulting from feeling glad for longer.”
It’s often self-administered.
“The most effective place to inject Mounjaro weight-loss pens is in your stomach or thighs, or again of the higher arms if another person is injecting for you,” says Basford. “Injections ought to be no less than one finger width out of your earlier injection web site, and if injecting within the stomach no less than 5cm away out of your naval.”
Nonetheless, Dutt is eager to emphasize that it isn’t a “miracle drug”.
“Whereas being an efficient weight-loss assist, it’s not a miracle drug,” notes Dutt. “It’s important that this remedy also needs to be launched along side different way of life modifications, comparable to a reduced-calorie weight loss program and train.”
Who’s eligible for Mounjaro?
“On the NHS, it is going to be provided to individuals with a physique mass index (BMI) of over 35 and no less than one obesity-related well being drawback – probably 3.4 million individuals,” says Basford. Nonetheless, the roll-out might be gradual.
NICE has beneficial prioritising sufferers receiving care from specialist weight-management providers who will be capable to entry the drug inside 90 days of the steering being revealed on December 23.
NHS England will develop a plan outlining different teams of sufferers that might be provided Mounjaro within the subsequent three years, in response to NICE.
(Alamy/PA)
“This remedy just isn’t for individuals with a wholesome BMI who need to slim down,” clarifies Dutt. “Mounjaro is just for people who find themselves medically overweight and want medical assist to succeed in a more healthy weight.”
Are there any recognized uncomfortable side effects?
“When beginning Mounjaro, you’ll be prescribed a beginning dose to start with to permit your physique to regulate to the remedy and get used to uncomfortable side effects,” explains Dutt. “The commonest side-effects of Mounjaro are just like different weight-loss injectables: nausea, diarrhoea, vomiting, constipation and indigestion.”
Tha do thaic gar cuideachadh gus an sgeulachd innse
Bho chòraichean gintinn gu atharrachadh clìomaid gu Massive Tech, tha The Unbiased air an talamh nuair a tha an sgeulachd a’ leasachadh. Co-dhiù a tha e a’ sgrùdadh ionmhas an pro-Trump PAC aig Elon Musk no a’ toirt a-mach am prògram aithriseach as ùire againn, ‘The A Phrase’, a tha a’ deàrrsadh air na boireannaich Ameireaganach a tha a’ strì airson còraichean gintinn, tha fios againn cho cudromach sa tha e na fìrinnean a sgrùdadh. teachdaireachdan.
Aig àm cho èiginneach ann an eachdraidh nan SA, tha feum againn air luchd-aithris air an talamh. Leigidh an tabhartas agad leinn cumail oirnn a’ cur luchd-naidheachd a bhruidhinn ri gach taobh den sgeulachd.
Tha earbsa aig Ameireaganaich thar an speactram poilitigeach gu lèir anns an Unbiased. Agus eu-coltach ri mòran ionadan naidheachd càileachd eile, tha sinn a’ roghnachadh gun a bhith a’ glasadh Ameireaganaich a-mach às ar n-aithris agus mion-sgrùdadh le ballachan pàighidh. Tha sinn den bheachd gum bu chòir naidheachdas càileachd a bhith ri fhaighinn leis a h-uile duine, le pàigheadh air a shon leis an fheadhainn as urrainn a phàigheadh.
Bidh an taic agad a’ dèanamh diofar mòr.
Thèid stealladh name cuideim Mounjaro, ris an canar cuideachd tirzepatide, a sgaoileadh air an SNS imply air mhean thar ùine 12 bliadhna.
Tha an Institiud Nàiseanta airson Sàr-mhathais Slàinte is Cùraim (NICE) Diardaoin gun tèid prìomhachas a thoirt do dhaoine leis na feumalachdan as àirde an toiseach, agus mar sin nas lugha na 10% de dh’ euslaintich ann an Sasainn a tha airidh air faighinn thuige an toiseach air an NHS.
Thuirt an t-Àrd-ollamh Jonathan Benger, prìomh oifigear meidigeach aig NICE: “Cuidichidh Tirzepatide agus drogaichean eile mar e, leithid semaglutide, daoine a tha beò le reamhrachd cuideam a chall, agus mar thoradh air sin lughdaichidh iad an cunnart bho bhith a’ faighinn tinneas cridhe no stròc. .
“Ach chan eil tirzepatide airson a h-uile duine, agus is e dìreach an fheadhainn leis an fheum clionaigeach as àirde a thèid a làimhseachadh an toiseach.
“Tha web optimization a’ ciallachadh gum feum mòran dhaoine feitheamh. Feumaidh sinn an co-dhùnadh duilich web optimization a dhèanamh gus seirbheisean deatamach SNS eile a dhìon agus cuideachd gus dòighean deuchainn a dhèanamh air a’ ghinealach ùr web optimization de chungaidhean name cuideim a lìbhrigeadh.”
Ach dè a th’ ann am Mounjaro, agus cò a bhios airidh air?
Dè th’ ann am Mounjaro?
“Is e Mounjaro an t-ainm branda airson tirzepatide, cungaidh-leigheis name cuideim seachdaineil a chaidh aontachadh o chionn ghoirid airson a chleachdadh san RA agus a tha a-nis ri fhaighinn airson òrdachadh le òrdugh air-loidhne,” thuirt an Dr Mitra Dutt, dotair-teaghlaich bho Dotair air-loidhne LloydsPharmacy. “Coltach ri mòran de na cungaidhean name cuideim a tha air a bhith rim faighinn anns na bliadhnachan mu dheireadh, chaidh Mounjaro a leasachadh bho thùs agus a cheadachadh mar chungaidh-leigheis dha daoine le tinneas tuiteamach. Tinneas an t-siùcair seòrsa 2.
“Is e tirzepatide an tàthchuid gnìomhach ann am Mounjaro. Bidh web optimization ag obair le bhith a’ dèanamh atharrais air buaidh nan hormonaichean GIP agus GLP-1 a tha falaichte bhon bhroinn às deidh ithe agus a tha a’ comharrachadh satieity don eanchainn, a’ toirt ort a bhith a’ faireachdainn làn, ”mhìnich an Dr Kathryn Basford aig Asda dotair air loidhne an. “Bidh e cuideachd a’ brosnachadh leigeil ma sgaoil insulin, hormone a bhios a’ lughdachadh siùcar fala, agus a’ slaodadh gluasad bìdh tron chnàimh.
“Thar ùine, cuidichidh a’ bhuaidh web optimization le name cuideim leis gu bheil daoine ag ithe nas lugha air sgàth ‘s gu bheil iad riaraichte nas fhaide.”
Mar as trice tha e fèin-rianachd.
“Is e an t-àite as fheàrr airson pinn name cuideim Mounjaro a thoirt a-steach nad bhroinn no na sliasaidean agad, no air cùl nan gàirdeanan àrda ma tha cuideigin eile a’ stealladh dhut, ”arsa Basford. “Bu chòir do in-stealladh a bhith co-dhiù aon leud meòir bhon làrach stealladh a bh’ agad roimhe, agus ma tha thu a ’stealladh a-steach don stomach co-dhiù 5 cm air falbh bhon chabhlach agad.”
Ach, tha Dutt airson a dhaingneachadh nach e “droga mìorbhuileach” a th’ ann.
“Ged a tha e na thaic èifeachdach airson name cuideim, chan e droga mìorbhuileach a th’ ann, ”thuirt Dutt. “Tha e cudromach gum bu chòir an cungaidh-leigheis web optimization a thoirt a-steach an co-bhonn ri atharrachaidhean dòigh-beatha eile, leithid daithead calorie nas lugha agus eacarsaich.”
Cò tha airidh air air an NHS?
“Air an NHS, thèid a thabhann do dhaoine le clàr-amais cuirp (BMI) de chòrr air 35 agus co-dhiù aon duilgheadas slàinte co-cheangailte ri reamhrachd – is dòcha 3.4 millean neach,” thuirt Basford. Ach, bidh an sgaoileadh a-mach imply air mhean.
Tha NICE air moladh prìomhachas a thoirt dha euslaintich a tha a’ faighinn cùram bho sheirbheisean stiùiridh cuideam sònraichte a gheibh cothrom air an droga taobh a-staigh 90 latha bho chaidh an stiùireadh fhoillseachadh air 23 Dùbhlachd.
Leasaichidh NHS Shasainn plana a mhìnicheas buidhnean euslaintich eile a thèid a thabhann do Mounjaro anns na trì bliadhna a tha romhainn, a rèir NICE.
“Chan eil an cungaidh-leigheis web optimization airson daoine le BMI fallain a tha a’ coimhead ri bhith a ’caolachadh,” tha Dutt a’ soilleireachadh. “Chan eil Mounjaro ach airson daoine a tha reamhar gu meidigeach agus a dh’ fheumas cuideachadh meidigeach gus cuideam nas fhallaine a ruighinn. ”
A bheil frith-bhuaidhean sam bith aithnichte?“Nuair a thòisicheas tu air Mounjaro, thèid dòs tòiseachaidh òrdachadh dhut an toiseach gus leigeil le do bhodhaig gabhail ris a’ chungaidh-leigheis agus fàs cleachdte ri frith-bhuaidhean, ”mhìnich Dutt. “Tha na fo-bhuaidhean as cumanta aig Mounjaro coltach ri stuthan name cuideim eile: nausea, a’ bhuineach, cuir a-mach, giorrachadh agus mì-rian.”
From reproductive rights to local weather change to Massive Tech, The Impartial is on the bottom when the story is creating. Whether or not it is investigating the financials of Elon Musk’s pro-Trump PAC or producing our newest documentary, ‘The A Phrase’, which shines a lightweight on the American girls preventing for reproductive rights, we all know how essential it’s to parse out the info from the messaging.
At such a important second in US historical past, we want reporters on the bottom. Your donation permits us to maintain sending journalists to talk to each side of the story.
The Impartial is trusted by Individuals throughout all the political spectrum. And in contrast to many different high quality information retailers, we select to not lock Individuals out of our reporting and evaluation with paywalls. We imagine high quality journalism must be obtainable to everybody, paid for by those that can afford it.
The NHS spending watchdog has really helpful Mounjaro – also referred to as tirzepatide and made by Eli Lilly – for these with a physique mass index (BMI) of greater than 35 and no less than one weight-related sickness.
That is estimated to account for about 3.4 million individuals.
To assist the NHS handle demand, Good stated about 220,000 individuals may gain advantage from the drug in an preliminary three-year interval. After this, the state of affairs can be reviewed by Good, who will present additional steering on the rollout.
Mounjaro is a glucagon-like peptide-1 (GLP-1) agonist, a household of medicines that assist handle blood sugar.
It was initially given the inexperienced gentle to assist handle weight problems on the NHS in June as a part of draft steering from Good.
The once-weekly jab must be prescribed alongside a reduced-calorie weight loss program and train to assist individuals drop some pounds.
Different GLP-1 agonists embrace semaglutide – offered underneath the model names Wegovy, Ozempic and Rybelsus.
Professor Jonathan Benger, chief medical officer at Good, stated: “Tirzepatide and different medicine prefer it, resembling semaglutide, will assist individuals dwelling with weight problems to drop some pounds, and because of this will cut back their danger of creating coronary heart illness or having a stroke.
“However tirzepatide isn’t for everyone, and solely these with the very best scientific want can be handled initially.
“This implies many individuals should wait. We’ve got needed to make this troublesome determination with a view to shield different important NHS providers and likewise to check methods of delivering this new technology of weight reduction drugs.”
Last draft steering revealed by Good reveals NHS England requested that Mounjaro is rolled out over 12 years.
The watchdog recommends prioritising sufferers receiving care from specialist weight administration providers who will have the ability to entry the drug inside 90 days of the steering being revealed on December 23.
The most recent Well being Survey for England reveals 64 per cent of adults had been obese or overweight in 2022.
Nonetheless, Dr Kath McCullough, NHS England’s nationwide speciality adviser for weight problems, warned that weight reduction jabs “are usually not a magic bullet”.
She stated: “On their very own, weight reduction medicine are usually not a magic bullet. They must be prescribed by a healthcare skilled alongside programmes that assist individuals drop some pounds and reside more healthy lives by making adjustments to their weight loss program and bodily exercise – and it’s additionally essential that they’re prioritised for individuals who want them most.”
It comes as a trial by Mounjaro producer Eli Lilly – generally known as Surmount-5 – discovered sufferers on tirzepatide recorded a weight lack of 20.2 per cent in comparison with 13.7 per cent in sufferers on semaglutide.
